Technology Search Results

Efforts under the direction of Dr. Webster Santos have, for the first time, demonstrated the potential of using N-terminal peptidic boronic acids as protease inhibitors, specifically for ClpXP, found in the human mitochondria matrix.

Development of selective inhibitors may provide research tools for investigating physiological functions of mitochondrial proteases.

The method describes the synthesis of mixed diboron reagents and their reactivity with various substrates. The method allows for the installation of a differentially protected boron onto the substrate; the orthogonal protection of boron allows the synthesis of complex molecular skeletons as synthetic intermediates or as drugs.

The technology is a fungal specific gene that is required for both pathogenesis of plants and animals. This gene is a novel, fungal specific drug target for a new class of antifungal drugs for mammalian therapeutics and novel fungicides for agricultural applications.

When selecting DNA subsequences to deal with a collection of organisms with known DNA sequences many techniques have been devised to select subsequences that are common to some of the organisms. There does not appear to be any well-known method to list all possible DNA subsequences of a fixed ...

Available for licensing are novel chemical compounds which are bifunctional and bind to the androgen receptor (AR), a ligand-dependent transcription factor. These compounds comprise tubulin-binding and steroid receptor-binding moieties. They are designed to antagonize AR function in a nonclassical manner by several mechanisms and kill hormone-refractory prostate cells better than ...